Group B streptococcal disease guideline

Group B Streptococcal Disease, Early-onset (Green-top Guideline No 36) | The Royal College of Obstetricians and Gynaecologists. 

Group B Streptococcal Disease (GBS) is recognised as the most frequent cause of severe early-onset infection in newborn infants. GBS is present in the bowel flora of 20–40% of adults (colonisation) and those who are colonised are called ‘carriers’. This includes pregnant women. There is variation in practice across the UK regarding the best strategies to prevent EOGBS disease.

In 2015, the incidence of EOGBS in the UK and Ireland was 0.57/1000 births (517 cases), a significant increase from the previous surveillance undertaken in 2000 where an incidence of 0.48/1000 was recorded.

The purpose of this guideline is to provide guidance for obstetricians, midwives and neonatologists on the prevention of early-onset (less than 7 days of age) neonatal group B streptococcal (EOGBS) disease and the information to be provided to women, their partners and families.

Group B Streptococcal Disease, Early-onset (Green-top Guideline No 36)


New Method for Predicting Congenital CMV Infection During the Prenatal Period

Tanimura, K. et al. (2016) Clinical Infectious Diseases. DOI:10.1093/cid/ciw707

Image source: Pete Jeffs – Wellcome Images // CC BY-NC-ND 4.0

Image shows illustration of a human cytomegalovirus (HCMV) virus particle

Background: The aim of this prospective study was to determine maternal clinical, laboratory, and ultrasound findings that effectively predict the occurrence of congenital cytomegalovirus (CMV) infection in high-risk pregnant women.

Conclusions: This is the first prospective cohort study to suggest that the presence of CMV-DNA in the maternal uterine cervical secretion and ultrasound fetal abnormalities was predictive of the occurrence of congenital CMV infection in high-risk pregnant women.

Read the full abstract here

Infectious diseases in pregnancy screening: clinical guidance

Information for healthcare professionals providing the NHS infectious diseases in pregnancy screening (IDPS) programme.

These documents explain the procedures for providing NHS infectious diseases in pregnancy screening (IDPS) in England, to ensure services meet the national standards.

Care pathways

See the typical care pathway for pregnant women screened for infectious diseases in pregnancy.

Service specifications

Infectious diseases in pregnancy screening professionals must use thenational service specifications in conjunction with these documents, to ensure service consistency in England.


The national quality assurance team uses key performance indicators (KPIs)to measure the performance of the antenatal and newborn screening programmes. Following the KPIs and standards for each programme ensures that all women receive an equitable screening experience.

Infectious diseases in pregnancy screening (IDPS): programme guidance

  1. Infectious diseases in pregnancy screening programme: laboratory handbook