Antimicrobial Resistance and Immunisation

Houses of Parliament | July 2018 |Antimicrobial Resistance and Immunisation

A new POSTnote, based on literature reviews and interviews with range of stakeholders, and externally peer reviewed, has been released from the House of Commons Library. This POSTnote considers the rise of antimicrobial resistance and immunisation. 

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Image source: researchbriefings.parliament.uk

Key points from the POSTNOTE:

  • Antimicrobial resistance (AMR) has reached a point where some infections may become untreatable.
  • Immunisation is one strategy to tackle AMR, by decreasing rates of infection and thereby antibiotic use and preventing the development of resistant infections.
  • The World Health Organization has developed a list of pathogens where AMR is of most concern and new antibiotics are needed; there is no equivalent for vaccines.
  • Quantifying the impact of immunisation on AMR and incorporating this into calculating the cost-effectiveness of vaccines is still an area of ongoing research.
  • Using immunisation to tackle AMR depends on wider use and increased uptake of existing vaccines, and increasing the development of new ones (Source: House of Commons Library).

The briefing Antimicrobial Resistance and Immunisation is available from the House of Commons Library 

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Brexit Health Alliance calls for co-operation on infectious diseases

The UK risks the spread of antibiotic-resistant and other infectious diseases if it leaves the European Union’s (EU) early warning system after Brexit without an effective replacement, the Brexit Health Alliance has warned.

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This briefing from the Brexit Health Alliance (BHA) and the Faculty of Public Health, a sets out how people across Europe currently benefit from the close collaboration between the UK and EU on public health, and proposes solutions to maintain and improve a high level of public health protection after the UK leaves the European Union.

The Alliance is calling for:

  • Both the EU Commission and UK government to prioritise the public’s health in negotiations on the future relationship between the UK and the EU.
  • A security partnership based on strong coordination between the UK and EU in dealing with serious cross-border health threats, such as pandemics, infectious diseases, safety of medicines (pharmacovigilance) and contamination of the food chain. Ideally, this would be by continuing access to the European Centre for Disease Prevention and Control and other relevant EU agencies, systems and databases.
  • Alignment with current and future EU regulatory and health and safety standards relating to (for example) food, medicines, transplant organs and the environment, to avoid the need for replication of inspections and non-tariff barriers at the UK/EU border.
  • The UK government to commit to a high level of human health protection when negotiating future free trade and investment agreements.

Full briefing: Protecting the public’s health across Europe after Brexit

Funding opportunity available to UK and Chinese researchers to help tackle antimicrobial resistance (AMR)

Department of Health and Social Care, Innovate UK & Steven Brine |  March 2018  | UK-China collaboration to tackle antimicrobial resistance

The Department of Health and Social Care (DHSC) will invest up to £10 million in UK businesses and academics who work in conjunction with Chinese scientists to advance work on antimicrobial resistance (AMR). The fund is to  support the development and, where appropriate, clinical evaluation of new products or services, which must be of value in addressing the threat from AMR.

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Innovate UK will deliver the funding to UK researchers (£750,000) and The Chinese Ministry of Science and Technology  will invest up to 60 million Renminbi (RMB) to fund the project.  Projects can last up to 3 years.

UK applicants must demonstrate that projects are primarily and directly relevant to the needs of people in low and middle income countries (LMICs), including China, as defined by the Organisation for Economic Co-operation and Development (OECD). There must be a clear economic and societal benefit to LMICs from their proposed project. The competition will open on 3 April 2018  (Innovation Funding Service)

Projects must address the specified criteria at DHSC here  

Full details including eligibility criteria are available from DHSC 

Progress report on the UK 5 year antimicrobial resistance strategy

The third annual progress report on the UK 5 year antimicrobial resistance (AMR) strategy, including future plans | Department of Health

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The third annual progress report describes the activities and achievements in the third year of implementation of the UK 5 year antimicrobial resistance (AMR) strategy 2013 to 2018, including significant international achievements.

The UK AMR strategy represents an ambitious programme to slow the development and spread of AMR, taking a ‘One Health’ approach spanning people, animals, agriculture and the wider environment.

The report sets out progress made in 2016, and notes that for the remaining 2 years of the strategy, the programme will focus on delivery of the government’s ambitions set out in response to the review on AMR led by Lord O’Neill. These include ambitions to halve certain types of infection and the inappropriate use of antibiotics.

Full report: UK 5 Year Antimicrobial Resistance (AMR) Strategy 2013-2018. Annual progress report, 2016

 

Preventing infections and reducing AMR

This professional resource outlines the importance of infection prevention and control and how it can contribute to reducing antimicrobial resistance (AMR) | Public Health England

Every infection prevented reduces the need for and use of antimicrobials, which in turn lessens the potential for development of resistance. In the UK, the current rising threat from drug resistant organisms is from Gram-negative bacteria. Infections caused by Gram-negative organisms are increasing. This professional resource outlines the importance of infection prevention and control and how it can contribute to reducing antimicrobial resistance.

Full detail at Public Health England

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Image source: http://www.gov.uk

 

Antibiotic awareness resources

Public Health England have published a series of antibiotic awareness resources to support the Antibiotic Guardian campaign and local initiatives.

Antibiotic awareness: toolkit for healthcare professionals in England
Guidance to help the NHS, local authorities and others support European Antibiotic Awareness Day and the Antibiotic Guardian campaign, to encourage responsible use of antibiotics.

Antibiotic awareness: quizzes and crosswords
Quizzes and crosswords about antibiotic resistance for the public, healthcare prescribers and pharmacists.

Antibiotics: secondary care prescriber’s checklist
Prescribers in secondary healthcare can use this checklist to help make decisions about prescribing antibiotics.

Antibiotic awareness: posters and leaflets
Posters and leaflets (in 11 languages) for the public and healthcare professionals to support antibiotic awareness campaigns in the UK.

PHE have also produced a short video to help explain the issue of antibiotic resistance:

Carbapenem-resistant Enterobacteriaceae in patients admitted to the Emergency Department

New risk factors and occurrence in patients coming directly from the community | Journal of Hospital Infection

Aim: To investigate the prevalence of patients harboring CRE on hospital admission, risk factors associated and the acquisition rate within the emergency department (ED).

Methods: We conducted a cross-sectional with 676 patients consecutively admitted to the ED study during the months of May to July 2016. A questionnaire was performed and rectal swabs were collected from patients on admission, for culture and for multiplex real-time polymerase chain-reaction (RT-PCR). If the patient was hospitalized for more than one week in the ED, samples were taken again to determine the acquisition rate of CRE.

Findings: Forty-six patients were colonized, all positive RT-PCR were KPC. The acquisition rate was 18%. Patients CRE colonized presented a higher mortality rate. Previous exposure to healthcare in the last year, liver disease and use of antibiotics in the last month were risk factors for colonization. Six patients with no previous exposure to healthcare were CRE-colonized on admission, suggesting transmission of CRE within the community.

Conclusion: Screening of high-risk patients on admission to the ED is a strategy to early identify CRE carriage and may contribute to control CRE dissemination.

Full reference: Salomão, M.C. et al. (2017) Carbapenem-resistant Enterobacteriaceae in patients admitted to the Emergency Department: new risk factors and occurrence in patients coming directly from the community. Journal of Hospital Infection. Published online: 18 August 2017